An Integrated Tool for Investigating Genetic Disorder-Relevant Tandem Repeats in Human Genome

Abstract

Tandem repeats (TRs) are associated with human inherited diseases, play a role in evolution, and are important in regulatory processes. Because experts who are researching in genetic disorders may be interested in TRs with particular limits, and they will design primer sequence for experiment. Hence, the objectives of this study are to integrate the information about human genetic disorders, and to provide an efficient tool for observing the information about TRs and genetic disorders are the objectives of this study. To reach the first objective we need to establish a database which integrates gene information, TRs, and OMIM data. Then users can efficiently analyze genetic disorders with this tool. We also need to provide a primer design tool for identifying specific TRs. Then users can obtain interesting primers from specific disease features and can experiment the patient's sample for verifying the suspect. This tool is designed with a user-friendly interface and integrated information for experts to analyze genetic disorders, such as the primer design. In this work, we identify TRs in the complete human genome from the publicly available sequences and mapped to the genes located in. According to the relationship of genes and genetic disorders recorded by OMIM, the TRs, which potentially relevant to the genetic disorders, will be shown.