Bioinformatics Approach to Detect Chromosomal Abnormality

Abstract

Since there occurs an unavoidable rearrangement of human DNA sequence during its transcription ,such a rearrangement will influence the expression of the protein amino acid sequence, which becomes important information on genetic engineering. The identification of chromosome abnormalities is an essential part of chromosome syndromes and many types of cancer involved in translocations, deletions, and inversions. The purpose of this paper is identification which genes prone to occurs abnormalities. Identification scope of all human’s EST sequence, quantity approximately are 8,000,000, will undergo judgment, alignment, analysis, as well as dynamic programming, will filter nearly 15,000, in which translocation and deletion and inversion event about 5000 and 9000 and 1000 respectively.