Template-based automatic segmentation of Drosophila mushroom bodies

Abstract

The segmentation of Drosophila mushroom bodies is highly demanded in the Drosophila brain research. In this work, we developed a template-based segmentation system with integration of the 3D average brain model. 3D registration and warping are performed to derive initial contours for the follow-up segmentation procedure which uses the snake algorithm. 3D models can be reconstructed from the segmentation results to update the average brain model. The proposed system can perform the segmentation fast and automatically to facilitate the construction of a more precise standard 3D Drosophila brain model.